Publications
2009
Lilley, CE, Chaurushiya, MS, Boutell, C, Landry, S, Suh, J, Panier, S, Everett, RD, Stewart, GS, Durocher, D and Weitzman, MD. A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and the cellular response to DNA damage. EMBO J (in press).
Lilley CE, Chaurushiya MS, Weitzman MD. Chromatin at the intersection of viral infection and DNA damage. Biochim Biophys Act. Special Issue: Chromatin in Viral Gene Regulation. Ed. P. Lieberman. 2009 Jul 17. [Epub ahead of print].
Chaurushiya MS and Weitzman MD. Viral manipulation of DNA repair and cell cycle checkpoints. DNA Repair (Amst). Special Issue: Checkpoint response to DNA damage. Ed. J. Petrini. 2009 Sep 2;8(9):1166-76.
Narvaiza I, Linfesty DC, Greener BN, Hakata Y, Pintel DJ, Logue E, Landau NR, Weitzman MD. Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase. PLoS Pathogens. 2009 May;5(5):e1000439.
Schwartz RA, Carson CT, Schuberth C, Weitzman MD. Adeno-associated virus replication induces a DNA damage response coordinated by DNA-PK. J Virol. 2009 Jun;83(12):6269-78.
Carson CT, Orazio NI, Lee DV, Suh J, Bekker-Jensen S, Araujo FD, Lakdawala SS, Lilley CE, Bartek J, Lukas J, Weitzman MD. Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J. 2009 Mar 18;28(6):652-62.
2008 [+]
Cervelli T, Palacios JA, Zentilin L, Mano M, Schwartz RA, Weitzman MD, Giacca M. Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins. J Cell Sci. 2008 Feb 1;121(Pt 3):349-57.
König R, Zhou Y, Elleder D, Diamond TL, Bonamy GM, Irelan JT, Chiang CY, Tu BP, De Jesus PD, Lilley CE, Seidel S, Opaluch AM, Caldwell JS, Weitzman MD, Kuhen KL, Bandyopadhyay S, Ideker T, Orth AP, Miraglia LJ, Bushman FD, Young JA, Chanda SK Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell. 2008 Oct 3;135(1):49-60.
Schwartz RA, Lakdawala SS, Eshleman HD, Russell MR, Carson CT, Weitzman MD. Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates. J Virol. 2008 Sep;82(18):9043-55.
Lakdawala SS, Schwartz RA, Ferenchak K, Carson CT, McSharry BP, Wilkinson GW, Weitzman MD. Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. J Virol. 2008 Sep;82(17):8362-72.
2007 [+]
Dheekollu J, Deng Z, Wiedmer A, Weitzman MD, Lieberman PM. A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes. PLoS ONE. 2007 Dec 5;2(12):e1257.
Schwartz RA, Palacios JA, Cassell GD, Adam S, Giacca M, Weitzman MD. The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication. J Virol. 2007 Dec;81(23):12936-45.
Fleisig HB, Orazio NI, Liang H, Tyler AF, Adams HP, Weitzman MD, Nagarajan L. Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes.Oncogene 2007 Jul 19;26(33):4797-805.
Lilley CE, Schwartz RA, Weitzman MD. Using or abusing: viruses and the cellular DNA damage response.Trends Microbiol. 2007 Mar;15(3):119-26.
2006 [+]
Hajitou A, Trepel M, Lilley CE, Soghomonyan S, Alauddin MM, Marini FC 3rd, Restel BH, Ozawa MG, Moya CA, Rangel R, Sun Y, Zaoui K, Schmidt M, von Kalle C, Weitzman MD, Gelovani JG, Pasqualini R, Arap W. A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell. 2006 Apr 21;125(2):385-98.
Chen H, Lilley CE, Yu Q, Lee DV, Chou J, Narvaiza I, Landau NR, Weitzman MD. APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. Curr Biol. 2006 Mar 7;16(5):480-5.
2005 [+]
Weitzman MD, Ornelles DA. Inactivating intracellular antiviral responses during adenovirus infection. Oncogene. 2005 Nov 21;24(52):7686-96. Review.
Araujo FD, Stracker TH, Carson CT, Lee DV, Weitzman MD. Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes. J Virol. 2005 Sep;79(17):11382-91
Alwin S, Gere MB, Guhl E, Effertz K, Barbas CF 3rd, Segal DJ, Weitzman MD, Cathomen T. Custom zinc-finger nucleases for use in human cells.
Mol Ther. 2005 Oct;12(4):610-7.
Verma IM, Weitzman MD. Gene therapy: twenty-first century medicine.
Annu Rev Biochem. 2005;74:711-38. Review.
Stracker TH, Lee DV, Carson CT, Araujo FD, Ornelles DA, Weitzman MD.
Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins. J Virol. 2005 Jun;79(11):6664-73.
Lilley CE, Carson CT, Muotri AR, Gage FH, Weitzman MD. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5844-9.
Weitzman MD. Functions of the adenovirus E4 proteins and their impact on viral vectors. Front Biosci. 2005 May 1;10:1106-17.
Weitzman MD, Thistlethwaite PA. Breaking the barriers to global gene delivery. Nat Biotechnol. 2005 Mar;23(3):305-6.
2004 [+]
Cassell GD, Weitzman MD. Characterization of a nuclear localization signal in the C-terminus of the adeno-associated virus Rep68/78 proteins. Virology. 2004 Oct 1;327(2):206-14.
Du L, Kido M, Lee DV, Rabinowitz JE, Samulski RJ, Jamieson SW, Weitzman MD, Thistlethwaite PA. Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors. Mol Ther. 2004 Sep;10(3):604-8.
Weitzman MD, Carson CT, Schwartz RA, Lilley CE. Interactions of viruses with the cellular DNA repair machinery. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1165-73. Review.
Arthur LM, Gustausson K, Hopfner KP, Carson CT, Stracker TH, Karcher A, Felton D, Weitzman MD, Tainer J, Carney JP. Structural and functional analysis of Mre11-3. Nucleic Acids Res. 2004 Mar 26;32(6):1886-93
Weitzman MD. Vector-omics? Mol Ther. 2004 Mar;9(3):315-7
Chu D, Thistlethwaite PA, Sullivan CC, Grifman MS, Weitzman MD. Gene delivery to the mammalian heart using AAV vectors. Methods Mol Biol. 2004;246:213-24.
Chu D, Sullivan CC, Du L, Cho AJ, Kido M, Wolf PL, Weitzman MD, Jamieson SW, Thistlethwaite PA. A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1.
Ann Thorac Surg. 2004 Feb;77(2):449-56; discussion 456-7.
Stracker TH, Cassell GD, Ward P, Loo YM, van Breukelen B, Carrington-Lawrence SD, Hamatake RK, van der Vliet PC, Weller SK, Melendy T, Weitzman MD. The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication. J Virol. 2004 Jan;78(1):441-53.
2003 [+]
Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV, Weitzman MD. The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J. 2003 Dec 15;22(24):6610-20.
Chu D, Sullivan CC, Weitzman MD, Du L, Wolf PL, Jamieson SW, Thistlethwaite PA. Direct comparison of efficiency and stability of gene transfer into the mammalian heart using adeno-associated virus versus adenovirus vectors.
J Thorac Cardiovasc Surg. 2003 Sep;126(3):671-9.
Muller OJ, Kaul F, Weitzman MD, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M. Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors. Nat Biotechnol. 2003 Sep;21(9):1040-6.
Porteus MH, Cathomen T, Weitzman MD, Baltimore D. Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks.
Mol Cell Biol. 2003 May;23(10):3558-65.
Weitzman MD. VP22 flips the switch on cell death.
Mol Ther. 2003 Feb;7(2):146-7.
Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb;111(4):469-78.
Weitzman MD, Young SM Jr, Cathomen T, Samulski RJ. Targeted integration by adeno-associated virus. Methods Mol Med. 2003;76:201-19.
2002 [+]
Loeb JE, Weitzman MD, Hope TJ. Enhancement of green fluorescent protein expression in adeno-associated virus with the woodchuck hepatitis virus post-transcriptional regulatory element. Methods Mol Biol. 2002;183:331-40.
Stracker TH, Carson CT, Weitzman MD. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature. 2002 Jul 18;418(6895):348-52.
2001 [+]
Cathomen T, Stracker TH, Gilbert LB, Weitzman MD. A genetic screen identifies a cellular regulator of adeno-associated virus.Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14991-6.
Grifman M, Trepel M, Speece P, Gilbert LB, Arap W, Pasqualini R, Weitzman MD. Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids. Mol Ther. 2001 Jun;3(6):964-75.
2000 and previous [+]
Cathomen T, Weitzman MD. A functional complex of adenovirus proteins E1B-55kDa and E4orf6 is necessary to modulate the expression level of p53 but not its transcriptional activity. J Virol. 2000 Dec;74(23):11407-12.
Trepel M, Grifman M, Weitzman MD, Pasqualini R. Molecular adaptors for vascular-targeted adenoviral gene delivery. Hum Gene Ther. 2000 Sep 20;11(14):1971-81.
Cathomen T, Collete D, Weitzman MD. A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay. J Virol. 2000 Mar;74(5):2372-82.
Grifman M, Chen NN, Gao GP, Cathomen T, Wilson JM, Weitzman MD. Overexpression of cyclin A inhibits augmentation of recombinant adeno-associated virus transduction by the adenovirus E4orf6 protein. J Virol. 1999 Dec;73(12):10010-9.
Loeb JE, Cordier WS, Harris ME, Weitzman MD, Hope TJ. Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy. Hum Gene Ther. 1999 Sep 20;10(14):2295-305.
Parry S, Holder J, Halterman MW, Weitzman MD, Davis AR, Federoff H, Strauss JF 3rd. Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry.
Am J Pathol. 1998 Jun;152(6):1521-9.
Weitzman MD, Kyostio SR, Carter BJ, Owens RA. Interaction of wild-type and mutant adeno-associated virus (AAV) Rep proteins on AAV hairpin DNA.
J Virol. 1996 Apr;70(4):2440-8
Weitzman MD, Fisher KJ, Wilson JM. Recruitment of wild-type and recombinant adeno-associated virus into adenovirus replication centers.
J Virol. 1996 Mar;70(3):1845-54.
Doucas V, Ishov AM, Romo A, Juguilon H, Weitzman MD, Evans RM, Maul GG. Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure. Genes Dev. 1996 Jan 15;10(2):196-207.
Fisher KJ, Gao GP, Weitzman MD, DeMatteo R, Burda JF, Wilson JM. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. J Virol. 1996 Jan;70(1):520-32.
Weitzman MD, Kyostio SR, Kotin RM, Owens RA. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5808-12.
